Now-a-days different newer approaches are introduced in the field of colon specific drug delivery system. This approaches having advantages for the treatment of colonic diseases like Ulcerative colitis, Crohn’s diseases, Inflammatory bowel diseases ,and also colon is selected as successful for site for oral administration of peptide and protein and can be protected from enzymatic degradation. Covalent linkage of drug with carrier is the newer approaches introduced now-a-days in which microbially triggered system is a novel approach of colon deals with specific enzyme activity of micro flora present in colon, like reducing and hydrolytic enzyme, and prodrug approaches deals with transformation of inactive derivative to the active drug at target site. So this article deals with different approaches used as microbially triggered system and its advantages and disadvantages.
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